The NFL is set to make history by hosting its first-ever regular-season game in Berlin, Germany, in 2025. This landmark event will take place at the iconic Olympic Stadium, a venue with deep ties to American football in Europe. The stadium previously hosted five American Bowl games between 1990 and 1994 and was home to NFL Europe's Berlin Thunder from 2003 to 2007 .​

The Indianapolis Colts have been designated as the home team for this inaugural Berlin game. This designation is part of the NFL's Global Markets Program, which aims to expand the league's presence internationally. The Colts were granted marketing rights in Germany in April 2024, reflecting the growing fanbase and interest in American football within the country .​

While the specific opponent, date, and time for the game have not yet been announced, the NFL has confirmed that the 2025 season will include multiple international games. In addition to the NFL Berlin game, there will be matches in London, Madrid, and potentially other locations as part of the league's expanded global schedule.